Japanese researchers used plasmids instead of viral vectors to deliver genes, and successfully cultivated induced pluripotent stem cells (iPS cells) using experimental mouse somatic cells. Scientists say the results of this research will help the popularization of this "universal cell" technology. Japan ’s Kyoto University and the Science and Technology Promotion Agency issued a joint press release on the 10th, saying that in the past, when iPS cells were cultivated, reversal was required
Enzyme virus or lentivirus introduces Oct3 / 4, Sox2, Klf4 and c-Myc into somatic cells, and the use of viral vectors may cause tumor formation. In addition, new virus vectors must be made before each experiment, which has strict requirements on the operation process and laboratory management, which hinders the popularization of iPS cell technology.
The research team of Professor Yamanaka Yamanaka of Kyoto University used two plasmids in the experiment, one plasmid carrying the "c-Myc" gene, and the other plasmid carrying the Oct3 / 4, Klf4, and Sox2 genes, and then introducing the two plasmids into the experimental mouse embryos at the same time. Fibroblasts successfully cultivated iPS cells.
Further experiments confirmed that the iPS cells cultured in this way can differentiate into epidermal, striated muscle, and nerve tissue cells like the previous iPS cells, but the transformation efficiency is lower than that using the retrovirus. The researchers say the next step is to improve the transformation efficiency and try to use new methods to grow adult mouse and human somatic cells into iPS cells. iPS cells, embryonic stem cells and adult stem cells are called "universal cells" because they can differentiate into organ and tissue cells. Many researchers believe that iPS cells do not involve ethical issues and have broader application prospects in the field of regenerative medicine.
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